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Tryptophan-substitution antimicrobial peptide temporin-1CEb: in vitro and in vivo antibacterial activity against clinically isolated multidrug-resistant <i>Klebsiella pneumoniae</i>

2025-12-30

Abstract excerpt

Tryptophan (Trp)-substitution antimicrobial peptides (AMPs) exhibit enhanced interactions with bacterial cell membranes, potentially improving their antimicrobial efficacy. K. pneumoniae (20.59% of 2054 ICU isolates) is resistant to multiple clinically used antibiotics and presents significant treatment challenges. In the present study, three Trp-modified peptides (I4W, L12W, and I1WL5W) were generated by substit...

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Literature Corpus work
b29c0342-fedf-505c-b676-7f8afc2e7536
DOI
10.64898/2025.12.30.696967
Open publication

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Tryptophan-substitution antimicrobial peptide temporin-1CEb: in vitro and in vivo antibacterial activity against clinically isolated multidrug-resistant <i>Klebsiella pneumoniae</i>DOI 10.64898/2025.12.30.696967
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