Development of novel broad-spectrum amphipathic antimicrobial peptides against multidrug-resistant bacteria through a rational combination strategy

Abstract excerpt

• A series of sC18 4b -derived cationic amphipathic antimicrobial peptides were designed by a combination strategy. • P-α-02-B, a screened analogue, displayed broad-spectrum and potent antimicrobial activity with high bacterial selectivity • P-α-02-B exhibited superior plasma stability, overcoming a major limitation of traditional AMPs. • When combined with levofloxacin, P-α-02-B showed a synergistic...

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