Article

D-amino acid substitution and cyclisation enhance the stability and antimicrobial activity of arginine-rich peptides

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Cationic peptides rich in arginine are potent antimicrobials but face challenges due to enzymatic degradation and potential host toxicity. We screened eight linear arginine-rich peptides for antimicrobial and haemolytic activity, identifying R4F4 as the most active. However, its efficacy decreased in the presence of human serum and trypsin. To enhance stability, we developed three R4F4 derivativ...

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Literature Corpus work: fa17b011-c91e-52b9-85b7-725538c84921
DOI: 10.1101/2025.06.17.660067

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