Article

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria

2022-12-01

Abstract excerpt

Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds infected with drug-resistant, biofilm-forming bacteria. The peptides tested are variants of an evolved AMP called D-CONGA, which has excellent antimicrobial activities in vitro and in vivo . In this newest generation of rational D-CONGA variants, we teste...

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Literature Corpus work: 44f1b5c0-2449-5743-816f-e19428bae4a5
DOI: 10.1101/2022.12.01.518642

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