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The interaction of SET and protein phosphatase 2A as target for cancer therapy

8 Jun 2021

Abstract excerpt

In cancer cells, tumor suppressor proteins loss-of-function are usually the result of genetic mutations. Protein Phosphatase 2A is a tumor suppressor that inactivates several signaling pathways through removal of phosphate residues important for other proteins stability and/or activation. Different from other tumor suppressors, PP2A is, in many cancer types, inactivated by endogenous inhibitors. In physiological...

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PMID: 34116173
DOI: 10.1016/j.bbcan.2021.188578

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