Article

Developing Cyclic Peptomers as Broad-Spectrum Gram negative Bacterial Type III Secretion System Inhibitors

2020-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic resistant bacteria are an emerging global health threat. New antimicrobials are urgently needed. The injectisome type III secretion system (T3SS), required by dozens of Gram-negative bacteria for virulence but largely absent from non-pathogenic bacteria, is an attractive antimicrobial target. We previously identified synthetic cyclic peptomers, inspired by the natural product pheprope...

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Literature Corpus work: b29124d6-858a-56dd-b2d3-e913bfd0300a
DOI: 10.1101/2020.08.03.235622

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