Article

Fighting the spread of antibiotic resistance with bacterial competence inhibitors

2019-06-27

Abstract excerpt

Streptococcus pneumoniae is a commensal of the human nasopharynx, but it can also cause severe life-threatening antibiotic-resistant infections. Antibiotic consumption drives the spread of resistance by inducing S. pneumoniae competence leading to the uptake of exogenous DNA and horizontal gene transfer (HGT). We have identified potent inhibitors of competence, collectively called COM-blockers. We show that COM-b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70cb72c2-017c-57cf-8dfc-548306f51b9e
DOI: 10.1101/683920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fighting the spread of antibiotic resistance with bacterial competence inhibitorsDOI 10.1101/683920Read

Strategies to attenuate the competence regulon in Streptococcus pneumoniaeSemantic proximity Read

Navigating collateral sensitivity: insights into the mechanisms and applications of antibiotic resistance trade-offsSemantic proximity Read

<i>Streptococcus mitis</i> bacteriocins drive contact-dependent lysis of <i>S. pneumoniae</i> facilitating transformation in multispecies environmentsSemantic proximity Read

Bacterial warfare is associated with virulence and antimicrobial resistanceSemantic proximity Read

Proton Motive Force Disruptors Block Bacterial Competence and Horizontal Gene TransferSemantic proximity Read

Perspective Approaches to “Trojan Horse” Strategy Development for Combating Bacterial PathogensSemantic proximity Read

Q&A: Antibiotic resistance: where does it come from and what can we do about it?Semantic proximity Read

A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniaeSemantic proximity Read

The Role of Macrolide Antibiotics in the Prevention of Severe COVID-19 Disease Progression Via the Disruption of Bacteria/virus Co-OperationSemantic proximity Read

Inhibition of pneumococcal growth and biofilm formation by human isolates of Streptococcus mitis and Streptococcus oralisSemantic proximity Read

The Case against Antibiotics and for Anti-Virulence TherapeuticsSemantic proximity Read

<i>ddcP, pstB</i> , and excess D-lactate impact synergism between vancomycin and chlorhexidine against <i>Enterococcus faecium</i> 1,231,410Semantic proximity Read