Article

A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

2022-02-08

Abstract excerpt

Bacterial type IV secretion systems (T4SSs) are macromolecular machines that translocate effector proteins across multiple membranes into infected host cells. Loss of function mutations in genes encoding protein components of the T4SS render bacteria avirulent, highlighting the attractiveness of T4SSs as drug targets. Here, we designed an automated high-throughput screening approach for the identification of compo...

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Literature Corpus work: 4fa13741-6821-59f9-ab53-2a31cbb04917
DOI: 10.1101/2022.02.07.479497

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A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion systemDOI 10.1101/2022.02.07.479497Read

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