Article

ALPN-101 (Acazicolcept) a Dual ICOS/CD28 Antagonist, Demonstrates Efficacy in Systemic Sclerosis Preclinical Mouse Models

2021-09-28

Abstract excerpt

<h4>Background: </h4> Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterised by generalized fibrosis affecting particularly the lungs and skin. Co-stimulatory molecules are key players during immune activation, and recent evidence supports a role of CD28 and ICOS in the development of fibrosis. We herein investigated the...

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Literature Corpus work: b28c423f-c79a-5054-8202-051f31b77da7
DOI: 10.21203/rs.3.rs-915978/v1

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