Article
Clinical and pathogenic significance of S100A4 overexpression in systemic sclerosis.
Annals of the rheumatic diseases - 1 Sept 2023
Denton Christopher P, Xu Shiwen, Zhang Fenge, Maclean Rory H, Clark Kristina E N, Borchert Signe, Hussain Rizwan I, Klingelhöfer Jörg, Hallén Jonas, Ong Voon H
Abstract excerpt
OBJECTIVES: We have studied the damage-associated molecular pattern protein S100A4 as a driver of fibroblast activation in systemic sclerosis (SSc). METHODS: S100A4 protein concentration was measured by ELISA in serum of SSc (n=94) and healthy controls (n=15). Protein expression in skin fibroblast cultures from diffuse cutaneous SSc (SScF, n=6) and healthy controls (normal fibroblasts (NF), n=6) was assessed....
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