Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo.

Frontiers in immunology - 1 Jan 2024

Le Tallec Erwan, Bellamri Nessrine, Lelong Marie, Morzadec Claudie, Frenger Quentin, Ballerie Alice, Cazalets Claire, Lescoat Alain, Gros Frédéric, Lecureur Valérie

Abstract excerpt

Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by antinuclear antibody production, which has been linked to an excess of apoptotic cells, normally eliminated by macrophages through efferocytosis. Additionally, circulating levels of CXCL4, a novel SSc biomarker, correlate with more severe fibrotic manifestations of the disease. Considering the defective efferocytosis of macrophages...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Phagocytosis

Share to Scleroderma, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 39464886
DOI: 10.3389/fimmu.2024.1468821
PMCID: PMC11512447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo.PMID 39464886Read ↗

LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patientsSemantic proximity Read ↗

Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease.Semantic proximity Read ↗

The Phenotypes and Functions of Neutrophils in Systemic Sclerosis.Semantic proximity Read ↗

Circulating monocytes from systemic sclerosis patients with progressive interstitial lung disease preferentially express M2 phenotype markers: in vitro and ex vivo study.Semantic proximity Read ↗

Patients with systemic sclerosis show phenotypic and functional defects in neutrophilsSemantic proximity Read ↗

Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung diseaseSemantic proximity Read ↗

Identification of Key Autophagy-related Genes and Potential Mechanisms in Systemic SclerosisSemantic proximity Read ↗

Immunoglobulin G of systemic sclerosis patients programs a pro-inflammatory and profibrotic phenotype in monocyte-like THP-1 cells.Semantic proximity Read ↗

CD81 and CD48 show different expression on blood eosinophils in systemic sclerosis: new markers for disease and pulmonary inflammation?Semantic proximity Read ↗

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosisSemantic proximity Read ↗

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory ResponsesSemantic proximity Read ↗

Efferocytosis and lung disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.