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Recent advances in animal models of systemic sclerosis

1 Jan 2016

Abstract excerpt

Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by the three cardinal pathological features, comprising aberrant immune activation, vasculopathy and tissue fibrosis, with unknown etiology. Although many inducible and genetic animal models mimicking the selected aspects of SSc have been well documented, the lack of models encompassing the full clinical manifestations hindered the...

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PMID: 26782003
DOI: 10.1111/1346-8138.13185

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