Article

ACSL4 Inhibition Prevents Macrophage Ferroptosis and Alleviates Fibrosis in Bleomycin-induced Systemic Sclerosis Model

2023-08-01

Abstract excerpt

<h4>Background: </h4> Systemic sclerosis (SSc), with unclear pathophysiology, is a paradigmatic rheumatic disease of immunity dysfunction driven multi-organ inflammation and ultimate fibrosis. Pathogenesis breakthroughs are urgently needed for available treatments halting its unremitting stiffness. This study aims to investigate whether ferroptosis can regulate the progressive SSc fibrosis. <h4>Methods: </h4> In...

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Literature Corpus work: d87005ef-d37b-501f-b851-247c43d3e3cd
DOI: 10.21203/rs.3.rs-3201833/v1

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