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CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model

2022-04-20

Abstract excerpt

<h4>Background: </h4> CD80 molecules interact with CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) on antigen-presenting cells, and function in the co-stimulatory signaling that regulates T cell activity. CTLA-4-Ig, a fusion of CTLA-4 and an immunoglobulin Fc fragment, is used to treat rheumatoid arthritis (RA) by blocking co-stimulatory signaling. We analyzed the therapeutic effect of CTLA-4-Ig in a...

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Literature Corpus work
ed58c09a-7065-56b0-b063-aa847f2bcaed
DOI
10.21203/rs.3.rs-1560115/v1
Open publication

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CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse modelDOI 10.21203/rs.3.rs-1560115/v1
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