Integrated analysis and annotation for T-cell receptor sequences using TCRosetta

Abstract excerpt

<h4>Background</h4> T cells and T cell receptors (TCRs) are essential components of the adaptive immune system. TCRs, on the surface of T cells, are responsible for recognizing and binding antigen peptide-MHC complex and play vital roles in T-cell immunology. Characterization of TCR repertoire offers a promising and high informative source for understanding the functions of T cells in immune responses and immunot...

Topics

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• Amino Acid Sequence
• CAR-T cell therapy research
• Complementarity Determining Regions
• Databases, Genetic
• High-Throughput Nucleotide Sequencing
• Immune Cell Function and Interaction
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

31d832e7-7df4-5111-8ed8-5c2f70f0d77b

DOI

10.1101/2023.02.20.529199