Article

Break-induced replication drives large-scale genomic amplifications in cancer cells

2024-08-28

Abstract excerpt

DNA double-strand breaks (DSBs) are highly toxic lesions that underly the efficacy of ionizing radiation (IR) and a large number of cytotoxic chemotherapies 1–3 . Yet, abnormal repair of DSBs is associated with genomic instability and may contribute to cancer heterogeneity and tumour evolution. Here, we show that DSBs induced by IR, by DSB-inducing chemotherapeutics, or by the expression of a rare-cutting restric...

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Literature Corpus work: b260f1b0-20b4-5058-8033-756e12be535a
DOI: 10.1101/2024.08.27.609980

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