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Article

PIF1 helicase promotes break-induced replication in mammalian cells.

The EMBO journal - 15 Apr 2021

Li Shibo, Wang Hailong, Jehi Sanaa, Li Jun, Liu Shuo, Wang Zi, Truong Lan, Chiba Takuya, Wang Zefeng, Wu Xiaohua

Abstract excerpt

Break-induced replication (BIR) is a specialized homologous-recombination pathway for DNA double-strand break (DSB) repair, which often induces genome instability. In this study, we establish EGFP-based recombination reporters to systematically study BIR in mammalian cells and demonstrate an important role of human PIF1 helicase in promoting BIR. We show that at endonuclease cleavage sites, PIF1-dependent BIR is...

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Identifiers

PMID: 33470420
DOI: 10.15252/embj.2020104509
PMCID: PMC8047440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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