Article

Highlighting the Major Role of Cyclin C on Cyclin-Dependent Kinase 8 Activity by Molecular Dynamics Simulations

2024-04-05

Abstract excerpt

Dysregulation of the Cyclin-dependent kinase 8 (CDK8) activity has been associated to many diseases including the colorectal and breast cancer. As usual in the CDK family, the activity of CDK8 is controlled by a regulatory protein called cyclin C (CycC). But while human CDK family members are generally activated in two steps that is, the binding of the cyclin to CDK and the phosphorylation of a residue in the CDK...

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Literature Corpus work: b22ec382-696d-5955-8e12-d3edb734c888
DOI: 10.20944/preprints202404.0426.v1

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