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Article

The Structural Perspective on CDK5

1 Jan 2003

Abstract excerpt

Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. In this review,...

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PMID: 14673202
DOI: 10.1159/000074617

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