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Article

Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach.

Human genomics - 5 Apr 2013

George Priya Doss C, Nagasundaram N, Chakraborty Chiranjib, Chen Luonan, Zhu Hailong

Abstract excerpt

BACKGROUND: Recent reports suggest the role of nonsynonymous single nucleotide polymorphisms (nsSNPs) in cyclin-dependent kinase 7 (CDK7) gene associated with defect in the DNA repair mechanism that may contribute to cancer risk. Among the various inhibitors developed so far, flavopiridol proved to be a potential antitumor drug in the phase-III clinical trial for chronic lymphocytic leukemia. Here, we described a...

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Identifiers

PMID: 23561625
DOI: 10.1186/1479-7364-7-10
PMCID: PMC3726351

Genes

CDK7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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