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Article

A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding.

Biochimica et biophysica acta - 1 Jul 2010

Child Emma S, Hendrychová Tereza, McCague Karen, Futreal Andy, Otyepka Michal, Mann David J

Abstract excerpt

Cyclin-dependent kinase 2 (cdk2) is a central regulator of the mammalian cell cycle. Here we describe the properties of a mutant form of cdk2 identified during large-scale sequencing of protein kinases from cancerous tissue. The mutation substituted a leucine for a proline in the PSTAIRE helix, the central motif in the interaction of the cdk with its regulatory cyclin subunit. We demonstrate that whilst the...

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Identifiers

PMID: 20399812
DOI: 10.1016/j.bbamcr.2010.04.004
PMCID: PMC3111755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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