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Article

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site.

International journal of molecular sciences - 12 Oct 2020

Xu Wu, Xie Xiao-Jun, Faust Ali K, Liu Mengmeng, Li Xiao, Chen Feng, Naquin Ashlin A, Walton Avery C, Kishbaugh Peter W, Ji Jun-Yuan

Abstract excerpt

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and Drosophila CDK8 proteins using molecular dynamics simulations, combined with functional analyses in Drosophila. Specifically, we evaluated the...

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Identifiers

PMID: 33053834
DOI: 10.3390/ijms21207511
PMCID: PMC7590003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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