Article
Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2.
International journal of molecular sciences - 24 Apr 2015
Li Yan, Zhang Jingxiao, Gao Weimin, Zhang Lilei, Pan Yanqiu, Zhang Shuwei, Wang Yonghua
Abstract excerpt
Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, these activation steps bring some dynamic changes on the 3D-structure of the kinase, especially the activation segment....
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