Article

<i>In vitro</i> and <i>in vivo</i> effects of zoledronate on senescence and senescence-associated secretory phenotype markers

2023-02-24

Abstract excerpt

<h4>ABSTRACT</h4> In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the se...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b224c6f0-6795-58db-a3dc-8cd625901008
DOI: 10.1101/2023.02.23.529777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vitro</i> and <i>in vivo</i> effects of zoledronate on senescence and senescence-associated secretory phenotype markersDOI 10.1101/2023.02.23.529777Read

The Potential Role and Therapeutic Relevance of Cellular Senescence in Skeletal PathophysiologySemantic proximity Read

Cellular Senescence: The Driving Force of Musculoskeletal DiseasesSemantic proximity Read

"Bone-SASP" in Skeletal Aging.Semantic proximity Read

Recent advances in senescence-associated secretory phenotype and osteoporosisSemantic proximity Read

Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damageSemantic proximity Read

Cellular senescence and other age-related mechanisms in skeletal diseasesSemantic proximity Read

Skeletal Aging and Osteoporosis: Mechanisms and TherapeuticsSemantic proximity Read

Identification of Senescent Cells in the Bone Microenvironment.Semantic proximity Read

Senescent cells: A therapeutic target for osteoporosisSemantic proximity Read

Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bonesSemantic proximity Read

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across TissuesSemantic proximity Read

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markersSemantic proximity Read