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ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

2022-12-29

Abstract excerpt

<h4>ABSTRACT</h4> Over the last decades, several premature aging mouse models have been developed to study aging and identify interventions that can delay age-related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. Here, we analyzed DNA methylation in multiple tissues of four previously reported mouse models of premature aging (ERCC1, LAKI, POLG and XPG). We estimated DNA...

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Literature Corpus work
b2008fb4-7d05-5ae5-b5cb-af05914b9d2a
DOI
10.1101/2022.12.28.522011
Open publication

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ERCC1 mice, unlike other premature aging models, display accelerated epigenetic ageDOI 10.1101/2022.12.28.522011
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