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Article

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

8 Mar 2016

Abstract excerpt

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespread effects. Here, we reveal a significant common transcriptomic signature in livers from hypothyroid mice, DNA...

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PMID: 26953569
DOI: 10.1371/journal.pone.0149941

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