Article

Screening, isolation and characterisation of antibodies that block aggrecanase activity of ADAMTS-5

2014-01-01

Abstract excerpt

A Disintegrin and Metalloproteinase with ThromboSpondin Motif (ADAMTS)-5 is considered to play a key role in degradation of aggrecan during the progression of osteoarthritis (OA). Thus, ADAMTS-5 inhibitors are emerging as potential disease-modifying OA drugs. The generation of small molecule inhibitors of metalloproteinases has not achieved successful outcomes primarily due to the lack of selectivity. On the other...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1fa62fd-0e34-59bf-94b5-0899c12d1ae4
DOI: 10.25560/22156

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Screening, isolation and characterisation of antibodies that block aggrecanase activity of ADAMTS-5DOI 10.25560/22156Read

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS FamilySemantic proximity Read

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Semantic proximity Read

Peptide-Based Inhibitors of ADAM and ADAMTS MetalloproteinasesSemantic proximity Read

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.Semantic proximity Read

The role of ADAMTSs in arthritisSemantic proximity Read

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.Semantic proximity Read

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6.Semantic proximity Read

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodiesSemantic proximity Read

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library.Semantic proximity Read

The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: in vitro and in vivo studiesSemantic proximity Read

Evaluation of antibodies directed against human protease-activated receptor-2Semantic proximity Read

ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.Semantic proximity Read