Article
Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library.
PloS one - 1 Jan 2020
Yano Hidenori, Nishimiya Daisuke, Kawaguchi Yoshirou, Tamura Masakazu, Hashimoto Ryuji
Abstract excerpt
Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the proteolysis of extracellular matrix components. Specific blocking of the active site of each MMP sheds light on its particular role. However, it remains difficult to acquire an active-site inhibitor with high specificity for only the target MMP due to the highly conserved structure around the active site of MMPs....
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