Article
The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6.
Open biology - 1 Aug 2016
Boschert V, Frisch C, Back J W, van Pee K, Weidauer S E, Muth E-M, Schmieder P, Beerbaum M, Knappik A, Timmerman P, Mueller T D
Abstract excerpt
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling. Neutralizing anti-sclerostin antibodies are able to restore Wnt activity and enhance bone growth thereby presenting a new osteoanabolic therapy approach for diseases such as...
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