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Article

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

1 Aug 1999

Abstract excerpt

Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the depletion of cartilage aggrecan due to increased proteolytic cleavage within the interglobular domain. Two major sites of cleavage have been identified in this region at Asn(341)-Phe(342) and Glu(373)-Ala(374). While several matrix metalloproteinases have been shown to cleave at...

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PMID: 10438522
DOI: 10.1074/jbc.274.33.23443

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