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Article

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.

Nature - 31 Mar 2005

Stanton Heather, Rogerson Fraser M, East Charlotte J, Golub Suzanne B, Lawlor Kate E, Meeker Clare T, Little Christopher B, Last Karena, Farmer Pamela J, Campbell Ian K, Fourie Anne M, Fosang Amanda J

Abstract excerpt

Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by one or more 'aggrecanases' from the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteinases. ADAMTS1, 8 and 9 have weak aggrecan-degrading activity. However, they are not thought to be the primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15800625
DOI: 10.1038/nature03417

Genes

ADAMTS5
ADAMTS1
ADAMTS4
ADAMTS8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.PMID 15800625Read ↗

The role of ADAMTSs in arthritisSemantic proximity Read ↗

Evidence of a novel aggrecan‐degrading activity in cartilage: Studies of mice deficient in both ADAMTS‐4 and ADAMTS‐5Semantic proximity Read ↗

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS FamilySemantic proximity Read ↗

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.Semantic proximity Read ↗

Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.Semantic proximity Read ↗

Transcriptomics of Wild‐Type Mice and Mice Lacking ADAMTS‐5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage DestructionSemantic proximity Read ↗

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.Semantic proximity Read ↗

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familySemantic proximity Read ↗

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.Semantic proximity Read ↗

Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis DevelopmentSemantic proximity Read ↗

The ADAMTS metalloproteinasesSemantic proximity Read ↗

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.Semantic proximity Read ↗

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