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Peptide-Based Inhibitors of ADAM and ADAMTS Metalloproteinases

21 Jul 2021

Abstract excerpt

ADAM and ADAMTS are two large metalloproteinase families involved in numerous physiological processes, such as shedding of cell-surface protein ectodomains and extra-cellular matrix remodelling. Aberrant expression or dysregulation of ADAMs and ADAMTSs activity has been linked to several pathologies including cancer, inflammatory, neurodegenerative and cardiovascular diseases. Inhibition of ADAM and ADAMTS...

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PMID: 34368231
DOI: 10.3389/fmolb.2021.703715

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