Article

Hematopoietic fitness of <i>JAK2<sup>V617F</sup></i> Myeloproliferative Neoplasms is linked to clinical outcome

2021-02-01

Abstract excerpt

Myeloproliferative Neoplasms (MPN) harbor highly recurrent driver mutations affecting targetable kinases yet treatment options for these phenotypically diverse diseases are limited, and patients experience significant morbidity and shortened survival. The most important disease-related complications—thrombosis, transformation and death—are not used as clinical trial endpoints due to the long follow-up required to...

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Literature Corpus work: b1e38acb-8d67-5f2a-b842-73fe3249c90c
DOI: 10.1101/2021.01.28.21250575

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