Article
Clonogenic assays improve determination of variant allele frequency of driver mutations in myeloproliferative neoplasms.
Annals of hematology - 1 Dec 2022
Kalmer Milena, Pannen Kristina, Lemanzyk Rebecca, Wirths Chiara, Baumeister Julian, Maurer Angela, Kricheldorf Kim, Schifflers Joelle, Gezer Deniz, Isfort Susanne, Brümmendorf Tim H, Koschmieder Steffen, Chatain Nicolas
Abstract excerpt
Molecular diagnostics moves more into focus as technology advances. In patients with myeloproliferative neoplasms (MPN), identification and monitoring of the driver mutations have become an integral part of diagnosis and monitoring of the disease. In some patients, none of the known driver mutations (JAK2V617F, CALR, MPL) is found, and they are termed "triple negative" (TN). Also, whole-blood variant allele...
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