Article
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms.
Nature genetics - 1 Feb 2024
Guo Jing, Walter Klaudia, Quiros Pedro M, Gu Muxin, Baxter E Joanna, Danesh John, Di Angelantonio Emanuele, Roberts David, Guglielmelli Paola, Harrison Claire N, Godfrey Anna L, Green Anthony R, Vassiliou George S, Vuckovic Dragana, Nangalia Jyoti, Soranzo Nicole
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example, JAK2V617F, are common in the population, yet only a minority of carriers develop MPN. Here we show that the inherited polygenic loci that underlie common hematological traits influence JAK2V617F clonal expansion. We identify polygenic risk scores (PGSs) for...
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