Article

Defining the chromatin and transcriptional landscape of stem cell-derived islets

2022-02-27

Abstract excerpt

Transplantation of insulin-secreting β-cells differentiated from human pluripotent stem cells holds great potential as a cell therapy for treating insulin-dependent diabetes. While these stem cell-derived islets (SC-islets) are able to reverse diabetes in animal models, they are not fully equivalent to their in vivo counterparts. To better define the state of the cell types generated within these SC-islets and pr...

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Literature Corpus work: 216cff80-ef08-55cb-bffe-485492645a48
DOI: 10.1101/2022.02.26.482126

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