Article

Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell–Derived and Primary Islets

2025-07-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The success of stem cell-derived islet (SC-islet) therapy for type 1 diabetes is limited by poor graft survival in the hypoxic post-transplantation microenvironment. While the response of SC-islets to chronic hypoxia has been studied, a direct comparison to primary human islets during the acute hypoxic phase has not been performed. Here, we conduct a comparative single-cell...

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Literature Corpus work: 57b0f259-27bc-5b33-b686-8d7b3ebcb1dc
DOI: 10.1101/2025.07.16.665006

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