Article

Small molecule agonists of 8-oxoguanine DNA glycosylase, OGG1

2026-01-31

Abstract excerpt

Base excision repair (BER) is the primary pathway that removes oxidatively-induced DNA base damage from the nuclear and mitochondrial genomes, with 8-oxoguanine DNA glycosylase (OGG1) initiating repair at the two most frequently-formed base lesions: 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxoGua) and 2,6-diamino-4-oxo-5-formamidopyrimidine (FapyGua). Humans expressing a catalytically-compromised variant of OGG1 (S3...

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Literature Corpus work: b1d099cc-0ef2-59d6-8f5d-8b38fa65c1b6
DOI: 10.64898/2026.01.30.702659

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