Article
Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.
Chemical research in toxicology - 21 Sept 2015
Alshykhly Omar R, Fleming Aaron M, Burrows Cynthia J
Abstract excerpt
Guanine (G) is a target for oxidation by reactive oxygen species in DNA, RNA, and the nucleotide pool. Damage to DNA yields products with alternative properties toward DNA processing enzymes compared to those of the parent nucleotide. A new lesion, 5-carboxamido-5-formamido-2-iminohydantoin (2Ih), bearing a stereocenter in the base was recently identified from the oxidation of G. DNA polymerase and base excision...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.