Adhesive implant interfaces prevent fibrosis by disrupting mechanobiological feedback

Abstract excerpt

Fibrotic encapsulation around medical implants affects millions of patients annually. Current approaches targeting inflammation or implant material properties have failed clinically, but the mechanical origins of implant-induced fibrosis remain unexplored. Here, we demonstrate that directional imbalance of mechanical forces (“tension anisotropy”) is the primary driver of fibroblast activation at implant-tissue int...

Topics

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• Anisotropy
• Biomechanical Phenomena
• Collagen
• Extracellular Matrix
• Fibroblasts
• Mice
• Phenotype
• Stress, Mechanical

Identifiers and source

Literature Corpus work

b1bf6610-b52b-5ab3-97dc-0d6b551ecd41

DOI

10.1101/2025.06.01.657311