Article

Lineage of origin-specific developmental programs drive the behaviors of malignant cells in an avian embryo model of human Medulloblastoma subgroups

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Tumoral cells of medulloblastoma (MB) subgroups (SHH, G3 and G4) display a close transcriptomic proximity to early neuronal progenitors that migrate to form the embryonic cerebellum. With the aim of exploring functional proximities between MB cells and their physiological counterparts, we established a model of transplantation of human MB cells into the cerebellum of chick embryos in vivo and ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1ae3033-436d-55ac-aacb-cc8ebec3c625
DOI: 10.1101/2025.10.09.681440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage of origin-specific developmental programs drive the behaviors of malignant cells in an avian embryo model of human Medulloblastoma subgroupsDOI 10.1101/2025.10.09.681440Read

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoidsSemantic proximity Read

Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapseSemantic proximity Read

A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse EmbryosSemantic proximity Read

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapseSemantic proximity Read

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testingSemantic proximity Read

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional ProgramsSemantic proximity Read

The site of origin of medulloblastoma: Does the neurosurgical perspective support the current concept from molecular data?Semantic proximity Read

Molecular architecture of the developing mouse brainSemantic proximity Read

Mapping pediatric brain tumors to their origins in the developing cerebellumSemantic proximity Read

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesisSemantic proximity Read

Distinct signaling center and progenitor identity dynamics initiate human forebrain patterningSemantic proximity Read

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts.Semantic proximity Read