Article

A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos

2025-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Medulloblastoma (MB) is the most prevalent malignant pediatric brain tumor. Its poor prognosis is driven by therapy-resistant cancer stem-like cells (CSCs), which are challenging to study in traditional preclinical models. MicroRNAs (miRNAs) modulate tumor-related pathways by repressing oncogenic gene expression, a function lost in cancer. We assessed the therapeutic potential of miRNA restorati...

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Literature Corpus work: c7403975-834b-5676-89e5-4a81232c40ff
DOI: 10.1101/2025.04.25.650572

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