Article

High-throughput CRISPR-mediated 3D enrichment platform for functional interrogation of chemotherapeutic resistance

2020-11-09

Abstract excerpt

Cancer is a disease of somatic mutations. These cellular mutations compete to dominate their microenvironment and dictate the disease outcome. While a therapeutic approach to target specific driver mutations helps to manage the disease, subsequent molecular evolution of tumor cells threatens to overtake therapeutic progress. There is need for rapid, high-throughput, unbiased in-vitro discovery screening platforms...

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Literature Corpus work: 54de1e30-0366-52b2-9665-9c54ff0eefdd
DOI: 10.22541/au.160495230.05907247/v1

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