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Combination therapy for HCC: from CRISPR screening to the design of clinical therapies

4 Oct 2021

Abstract excerpt

CRISPR screening has been broadly used to discover new therapy targets, but these finding’ successful clinical transition is still limited. In a recent study published in Nature, Jin et al. 1 adopted CRISPR screening to dissect the resistance of hepatocellular carcinoma to lenvatinib, discovering the synergistic effect of EGFR inhibitor (gefitinib) and lenvatinib (multi-tyrosine kinase inhibitor, muti-TKI)...

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Share to Colorectal Cancer Treatments and Studies
Share to Hepatocellular Carcinoma Treatment and Prognosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34608130
DOI: 10.1038/s41392-021-00775-1

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