Article

Dynamic programming algorithms for fast and accurate cell lineage tree reconstruction from CRISPR-based lineage tracing data

2024-11-16

Abstract excerpt

CRISPR-based lineage tracing, coupled with single-cell RNA sequencing, has emerged as a promising approach for studying cell transformations during development as well as disease progression. However, the high ratio of cells to CRISPR-induced mutations, combined with missing data from silencing or dropout, make cell lineage tree (CLT) reconstruction difficult. As a result, this computational problem has attracted...

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Literature Corpus work: b19d902a-8cfb-5558-9784-59bc5b09c0e2
DOI: 10.1101/2024.11.15.623872

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