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Article

Deep distributed computing to reconstruct extremely large lineage trees.

Nature biotechnology - 1 Apr 2022

Konno Naoki, Kijima Yusuke, Watano Keito, Ishiguro Soh, Ono Keiichiro, Tanaka Mamoru, Mori Hideto, Masuyama Nanami, Pratt Dexter, Ideker Trey, Iwasaki Wataru, Yachie Nozomu

Abstract excerpt

Phylogeny estimation (the reconstruction of evolutionary trees) has recently been applied to CRISPR-based cell lineage tracing, allowing the developmental history of an individual tissue or organism to be inferred from a large number of mutated sequences in somatic cells. However, current computational methods are not able to construct phylogenetic trees from extremely large numbers of input sequences. Here, we...

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PMID: 34992246
DOI: 10.1038/s41587-021-01111-2
PMCID: PMC9934975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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