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Article

Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data.

Nature communications - 16 Jun 2020

Zafar Hamim, Lin Chieh, Bar-Joseph Ziv

Abstract excerpt

Recent studies combine two novel technologies, single-cell RNA-sequencing and CRISPR-Cas9 barcode editing for elucidating developmental lineages at the whole organism level. While these studies provided several insights, they face several computational challenges. First, lineages are reconstructed based on noisy and often saturated random mutation data. Additionally, due to the randomness of the mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32546686
DOI: 10.1038/s41467-020-16821-5
PMCID: PMC7298005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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