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Article

Startle: A star homoplasy approach for CRISPR-Cas9 lineage tracing.

Cell systems - 20 Dec 2023

Sashittal Palash, Schmidt Henri, Chan Michelle, Raphael Benjamin J

Abstract excerpt

CRISPR-Cas9-based genome editing combined with single-cell sequencing enables the tracing of the history of cell divisions, or cellular lineage, in tissues and whole organisms. Although standard phylogenetic approaches may be applied to reconstruct cellular lineage trees from this data, the unique features of the CRISPR-Cas9 editing process motivate the development of specialized models that describe the...

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Identifiers

PMID: 38128483
DOI: 10.1016/j.cels.2023.11.005
PMCID: PMC11257033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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