Article

Transcriptome-wide analysis of primary human endothelial cell responses to 1 hour of protein translation inhibition identify nonsense mediated decay targets and a non-coding <i>SLC11A2</i> exon as an acute biomarker

2023-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Nonsense mediated decay (NMD) lowers the cellular concentration of spliced RNAs harboring premature termination codons (PTC), and inhibition has been proposed as a potential therapeutic method. Conversely, NMD plays regulatory roles throughout the eukaryotic kingdom, including when protein translation is inhibited acutely as part of the integrated stress response. To define tools for endothelial...

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Literature Corpus work: b191b04f-aa67-57fc-8492-306d2f62fa40
DOI: 10.1101/2023.09.21.558767

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Transcriptome-wide analysis of primary human endothelial cell responses to 1 hour of protein translation inhibition identify nonsense mediated decay targets and a non-coding <i>SLC11A2</i> exon as an acute biomarkerDOI 10.1101/2023.09.21.558767Read

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