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Article

Expanding small-molecule target space to mRNA translation regulation

6 Dec 2020

Abstract excerpt

Multiple layers of regulation are in place on mRNA translation to ensure that cells respond in a fast manner to environmental cues in a tissue-specific and mRNA-selective manner. Here, we discuss mRNA translation regulatory mechanisms and potential drug-intervention targets. Taking on a new scientific rational of translation regulation and consequently a new target space, we have developed a unique discovery...

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PMID: 33296694
DOI: 10.1016/j.drudis.2020.11.017

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